Difference Between Glycolysis and Krebs Cycle:
Following are the points of difference between Glycolysis and Krebs Cycle-
|Glycolysis (EMP Pathway)
|Krebs Cycle (TCA or Citric Acid Cycle)
|Glycolysis takes place in the cytoplasm.
|Krebs Cycle takes place in the matrix of mitochondria (exception aerobic procaryotes).
|It is a common pathway for both aerobic and anaerobic respiration.
|It is restricted to only aerobic respiration.
|Oxygen is not required for glycolysis.
|Krebs Cycle uses oxygen as a terminal oxidant.
|It is a straight or linear pathway.
|It is a cyclic pathway.
|Glycolysis is the first step of respiration in which glucose is broken down to the level of pyruvate.
|The Krebs cycle is the second step in respiration where an active acetyl group is broken down completely.
|It degrades a molecule of glucose into 2 molecules of organic substance pyruvate.
|It degrades pyruvate completely into inorganic substances (CO2 + H2O).
|Glycolysis uses two molecules of ATP.
|Krebs Cycle does not consume any ATP molecules.
|Generates 4 ATP, so there is a net gain of 2 ATP molecules.
|Generates 2 GTP molecules from 2 pyruvate molecules.
|It generates 2 NADH (+H+) molecules.
|Krebs Cycle produces 6 NADH (+H+) and 2 FADH2 molecules. 2 NADH (+H+) are additionally formed through link reaction.
|It is not linked to electron transport or oxidative phosphorylation.
|It is linked to electron transport or oxidative phosphorylation.