Important Difference Between Glycolysis and Krebs Cycle

Difference Between Glycolysis and Krebs Cycle:

Following are the points of difference between Glycolysis and Krebs Cycle-

Glycolysis (EMP Pathway)	Krebs Cycle (TCA or Citric Acid Cycle)
Glycolysis takes place in the cytoplasm.	Krebs Cycle takes place in the matrix of mitochondria (exception aerobic procaryotes).
It is a common pathway for both aerobic and anaerobic respiration.	It is restricted to only aerobic respiration.
Oxygen is not required for glycolysis.	Krebs Cycle uses oxygen as a terminal oxidant.
It is a straight or linear pathway.	It is a cyclic pathway.
Glycolysis is the first step of respiration in which glucose is broken down to the level of pyruvate.	The Krebs cycle is the second step in respiration where an active acetyl group is broken down completely.
It degrades a molecule of glucose into 2 molecules of organic substance pyruvate.	It degrades pyruvate completely into inorganic substances (CO₂ + H₂O).
Glycolysis uses two molecules of ATP.	Krebs Cycle does not consume any ATP molecules.
Generates 4 ATP, so there is a net gain of 2 ATP molecules.	Generates 2 GTP molecules from 2 pyruvate molecules.
It generates 2 NADH (+H⁺) molecules.	Krebs Cycle produces 6 NADH (+H⁺) and 2 FADH₂molecules. 2 NADH (+H⁺) are additionally formed through link reaction.
It is not linked to electron transport or oxidative phosphorylation.	It is linked to electron transport or oxidative phosphorylation.